William M Perlstein

William M Perlstein, Ph.D.

ASSOCIATE PROFESSOR

Department: Department of Clinical and Health Psychology
Business Phone: (352) 273-6139
Business Email: wmp@phhp.ufl.edu

Clinical Profile

Specialties
  • Psychology
Subspecialties
  • Clinical Health Psychology
Areas of Interest
  • Generalized anxiety disorder
  • Neurosciences
  • Traumatic Brain Injury

Research Profile

Dr. Perlstein’s research interests include Cognitive Neuroscience, Experimental Psychopathology, Emotion Neuroscience, Anxiety Disorders, Traumatic Brain Injury, Psychophysiology, Functional Neuroimaging.

Publications

2020
The influence of traumatic brain injury on the allocation of vertical spatial attention.
Journal of clinical and experimental neuropsychology. 42(1):101-110 [DOI] 10.1080/13803395.2019.1685650. [PMID] 31665971.
2019
Prevalence and Correlates of Psychological Distress among Retired Elite Athletes: A Systematic Review.
International review of sport and exercise psychology. 12(1):265-294 [DOI] 10.1080/1750984X.2018.1469162. [PMID] 31217807.
2018
Gray Matter Changes Following Cognitive Behavioral Therapy for Patients With Comorbid Fibromyalgia and Insomnia: A Pilot Study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 14(9):1595-1603 [DOI] 10.5664/jcsm.7344. [PMID] 30176973.
2018
Socioeconomic Status and Race Outperform Concussion History and Sport Participation in Predicting Collegiate Athlete Baseline Neurocognitive Scores.
Journal of the International Neuropsychological Society : JINS. 24(1):1-10 [DOI] 10.1017/S1355617717000716. [PMID] 28791942.
2017
Low-to-Moderate Alcohol Consumption is Associated With Hippocampal Volume in Fibromyalgia and Insomnia.
Behavioral sleep medicine. 15(6):438-450 [DOI] 10.1080/15402002.2016.1150279. [PMID] 27144807.
2016
An Event-Related Potential Investigation of the Effects of Age on Alerting, Orienting, and Executive Function.
Frontiers in aging neuroscience. 8 [DOI] 10.3389/fnagi.2016.00099. [PMID] 27242511.
2016
Apathy, Novelty Processing, and the P3 Potential in Parkinson’s Disease.
Frontiers in neurology. 7 [DOI] 10.3389/fneur.2016.00095. [PMID] 27445962.
2016
Orbitofrontal Cortex and the Early Processing of Visual Novelty in Healthy Aging.
Frontiers in aging neuroscience. 8 [DOI] 10.3389/fnagi.2016.00101. [PMID] 27199744.
2015
Fibromyalgia patients have reduced hippocampal volume compared with healthy controls.
Journal of pain research. 8:47-52 [DOI] 10.2147/JPR.S71959. [PMID] 25674013.
2015
Sleep is associated with task-negative brain activity in fibromyalgia participants with comorbid chronic insomnia.
Journal of pain research. 8:819-27 [DOI] 10.2147/JPR.S87501. [PMID] 26648751.
2015
Visuospatial attention after traumatic brain injury: The role of hemispheric specialization.
Brain injury. 29(13-14):1617-29 [DOI] 10.3109/02699052.2015.1075155. [PMID] 26451899.
2014
Bilateral Hippocampal Volume Reductions in Fibromyalgia
Journal of Pain. 15(4, 1)
2014
Immediate changes after manual therapy in resting-state functional connectivity as measured by functional magnetic resonance imaging in participants with induced low back pain.
Journal of manipulative and physiological therapeutics. 37(9):614-27 [DOI] 10.1016/j.jmpt.2014.09.001. [PMID] 25284739.
2014
Response to goal management training in veterans with blast-related mild traumatic brain injury.
Journal of rehabilitation research and development. 51(10):1555-66 [DOI] 10.1682/JRRD.2013.12.0266. [PMID] 25860148.
2013
Chronic Resveratrol Supplementation and Brain Oxygenation: a Pilot Study
Gerontologist. 53(1)
2013
Functional connectivity of the default mode network and its association with pain networks in irritable bowel patients assessed via lidocaine treatment.
The journal of pain. 14(10):1077-87 [DOI] 10.1016/j.jpain.2013.04.003. [PMID] 23743257.
2013
Regional Gray Matter Predicts Placebo Response: a Study of Endogenous Pain Modulation in Healthy Individuals
Journal of Pain. 14
2013
Structural and functional changes of the cingulate gyrus following traumatic brain injury: relation to attention and executive skills.
Journal of the International Neuropsychological Society : JINS. 19(8):899-910 [DOI] 10.1017/S135561771300074X. [PMID] 23845701.
2013
The late positive potential, emotion and apathy in Parkinson’s disease.
Neuropsychologia. 51(5):960-6 [DOI] 10.1016/j.neuropsychologia.2013.01.001. [PMID] 23320979.
2013
Within-session practice eliminates age differences in cognitive control.
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. 20(5):522-31 [DOI] 10.1080/13825585.2012.736469. [PMID] 23116428.
2012
Cognition Results From the Resveratrol for Improved Performance in Elders (Ripe) Trial
Gerontologist. 52
2012
Effective connectivity among brain regions associated with slow temporal summation of C-fiber-evoked pain in fibromyalgia patients and healthy controls.
The journal of pain. 13(4):390-400 [DOI] 10.1016/j.jpain.2012.01.002. [PMID] 22480771.
2012
Sleep Predicts Resting Brain Activity in Fibromyalgia Participants With Insomnia
Sleep. 35
2011
Detecting Emotional Significance: the Late Positive Potential in Parkinson’S Disease
Psychophysiology. 48
2011
Error-related processing following severe traumatic brain injury: an event-related functional magnetic resonance imaging (fMRI) study.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 82(1):97-106 [DOI] 10.1016/j.ijpsycho.2011.06.019. [PMID] 21756946.
2011
Feeling Antsy About the “Golden Years?” An Event-Related Potential Investigation of the Effects of Age On Three Interactive Attentional Networks
Psychophysiology. 48
2011
Gray matter volumes of pain-related brain areas are decreased in fibromyalgia syndrome.
The journal of pain. 12(4):436-43 [DOI] 10.1016/j.jpain.2010.10.003. [PMID] 21146463.
2011
Predictors of performance monitoring abilities following traumatic brain injury: the influence of negative affect and cognitive sequelae.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 82(1):61-8 [DOI] 10.1016/j.ijpsycho.2011.02.001. [PMID] 21315777.
2011
Psychophysiology and brain imaging of cognition and affect following traumatic brain injury: an overview of the special issue.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 82(1):1-3 [DOI] 10.1016/j.ijpsycho.2011.07.013. [PMID] 21820016.
2010
Operating characteristics of executive functioning tests following traumatic brain injury.
The Clinical neuropsychologist. 24(8):1292-308 [DOI] 10.1080/13854046.2010.528452. [PMID] 21069617.
2009
Awareness of deficits and error processing after traumatic brain injury.
Neuroreport. 20(16):1486-90 [DOI] 10.1097/WNR.0b013e32833283fe. [PMID] 19809369.
2009
Conflict adaptation and cognitive control adjustments following traumatic brain injury.
Journal of the International Neuropsychological Society : JINS. 15(6):927-37 [DOI] 10.1017/S1355617709990701. [PMID] 19765356.
2009
Double jeopardy! The additive consequences of negative affect on performance-monitoring decrements following traumatic brain injury.
Neuropsychology. 23(4):433-44 [DOI] 10.1037/a0015723. [PMID] 19586208.
2009
Neural substrates of object identification: Functional magnetic resonance imaging evidence that category and visual attribute contribute to semantic knowledge.
Journal of the International Neuropsychological Society : JINS. 15(2):169-81 [DOI] 10.1017/S1355617709090468. [PMID] 19232155.
2009
Neural time course of conflict adaptation effects on the Stroop task.
Neuropsychologia. 47(3):663-70 [DOI] 10.1016/j.neuropsychologia.2008.11.013. [PMID] 19071142.
2009
Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors: evidence from human psychophysics, animal models, and neuroimaging.
NeuroImage. 47(3):995-1001 [DOI] 10.1016/j.neuroimage.2009.04.028. [PMID] 19375508.
2008
Age-related changes in word retrieval: role of bilateral frontal and subcortical networks.
Neurobiology of aging. 29(3):436-51 [PMID] 17147975.
View on: PubMed
2008
The dynamic mechanisms of placebo induced analgesia: Evidence of sustained and transient regional involvement.
Pain. 139(3):660-669 [DOI] 10.1016/j.pain.2008.07.025. [PMID] 18804916.
2007
Brain activity related to temporal summation of C-fiber evoked pain.
Pain. 129(1-2):130-42 [PMID] 17156923.
View on: PubMed
2007
Brain activity related to temporal summation of C-fiber evoked pain.
Pain. 129(1-2):130-42 [PMID] 17156923.
View on: PubMed
2007
Functional brain interactions that serve cognitive-affective processing during pain and placebo analgesia.
NeuroImage. 38(4):720-9 [PMID] 17904390.
View on: PubMed
2007
Individualized piano instruction enhances executive functioning and working memory in older adults.
Aging & mental health. 11(4):464-71 [PMID] 17612811.
View on: PubMed
2007
Performance monitoring, error processing, and evaluative control following severe TBI.
Journal of the International Neuropsychological Society : JINS. 13(6):961-71 [PMID] 17942014.
View on: PubMed
2007
Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients.
Pain. 127(1-2):63-72 [PMID] 16963184.
View on: PubMed
2007
Reward context sensitivity impairment following severe TBI: an event-related potential investigation.
Journal of the International Neuropsychological Society : JINS. 13(4):615-25 [PMID] 17521495.
View on: PubMed
2006
Affective context-induced modulation of the error-related negativity.
Neuroreport. 17(3):329-33 [PMID] 16462607.
View on: PubMed
2006
Cognitive control impairments in traumatic brain injury.
Journal of clinical and experimental neuropsychology. 28(6):968-86 [PMID] 16822736.
View on: PubMed
2006
Temporal dissociation of components of cognitive control dysfunction in severe TBI: ERPs and the cued-Stroop task.
Neuropsychologia. 44(2):260-74 [PMID] 15979655.
View on: PubMed
2005
Cognitive control in closed head injury: context maintenance dysfunction or prepotent response inhibition deficit?
Neuropsychology. 19(5):578-90 [PMID] 16187876.
View on: PubMed
2004
Parametric manipulation of working memory load in traumatic brain injury: behavioral and neural correlates.
Journal of the International Neuropsychological Society : JINS. 10(5):724-41 [PMID] 15327720.
View on: PubMed
2003
Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia.
Biological psychiatry. 53(1):25-38 [PMID] 12513942.
View on: PubMed
2003
Steady-state visual evoked potentials reveal frontally-mediated working memory activity in humans.
Neuroscience letters. 342(3):191-5 [PMID] 12757897.
View on: PubMed
2002
Dissociation in human prefrontal cortex of affective influences on working memory-related activity.
Proceedings of the National Academy of Sciences of the United States of America. 99(3):1736-41 [PMID] 11818573.
View on: PubMed
2001
Prepulse effects as a function of cortical projection system.
Biological psychology. 56(2):83-111 [PMID] 11334698.
View on: PubMed
2001
Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia.
The American journal of psychiatry. 158(7):1105-13 [PMID] 11431233.
View on: PubMed
1999
Increased stroop facilitation effects in schizophrenia are not due to increased automatic spreading activation.
Schizophrenia research. 39(1):51-64 [PMID] 10480667.
View on: PubMed
1998
Functional hypofrontality and working memory dysfunction in schizophrenia.
The American journal of psychiatry. 155(9):1285-7 [PMID] 9734557.
View on: PubMed
1998
Selective pharmacological activation of limbic structures in human volunteers: a positron emission tomography study.
The Journal of neuropsychiatry and clinical neurosciences. 10(2):148-59 [PMID] 9608403.
View on: PubMed
1998
The Stroop task and attention deficits in schizophrenia: a critical evaluation of card and single-trial Stroop methodologies.
Neuropsychology. 12(3):414-25 [PMID] 9673997.
View on: PubMed
1997
Anxiety disorders and the syndrome of chest pain with normal coronary arteries: prevalence and pathophysiology.
The Journal of clinical psychiatry. 58 Suppl 3:70-3; discussion 74 [PMID] 9133495.
View on: PubMed
1997
Pharmacologic activation of limbic structures and neuroimaging studies of emotions.
The Journal of clinical psychiatry. 58 Suppl 16:13-5 [PMID] 9430504.
View on: PubMed
1997
Temporal dynamics of brain activation during a working memory task.
Nature. 386(6625):604-8 [PMID] 9121583.
View on: PubMed
1993
Lead stimulation effects on reflex blink, exogenous brain potentials, and loudness judgments.
Psychophysiology. 30(4):347-58 [PMID] 8327620.
View on: PubMed
1990
Sensation-seeking: electrodermal and behavioral effects of stimulus content and intensity.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 9(2):179-88 [PMID] 2228752.
View on: PubMed
1987
The P300 metric in schizophrenia: effects of probability and modality.
Electroencephalography and clinical neurophysiology. Supplement. 40:670-4 [PMID] 2891497.
View on: PubMed

Grants

Sep 2011 – Mar 2016
Florida Trauma Rehabilitation Center for Returning Military Personnel
Role: Project Manager
Funding: US DEPT OF DEFENSE
Jul 2008 – Dec 2020
TO SUPPORT RESEARCH IN THE CLINICAL-COGNITIVE NEUROSCIENCE LABORATORY
Role: Principal Investigator
Funding: **UF FOU UNRESTRICTED DONATION
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Education

Psychology (clinical) and Psychophysiology
1994 · University of Delaware
M.A. Psychology (clinical)
1989 · University of Delaware

Teaching Profile

Courses Taught
2019-2021
CLP4302 Introduction to Clinical Psychology
2013-2021
CLP6971 Research for Master’s Thesis
2019-2021
CLP3911 Introduction to Clinical Research
2009-2011,2013-2021,2019-2021
CLP7980 Research for Doctoral Dissertation
2007,2009-2021
CLP7934 Special Topics In Clinical Psychology
2009-2010,2013-2021
CLP7979 Advanced Research
2020
CLP6430 Clinical Psychological Assessment
2020
CLP6940 Supervised Teaching
2015-2019
HSC4608L Critical Thinking in Health Care
2018
GMS7979 Advanced Research
2013-2016,2018
CLP6947 Practicum in Intervention
2015
CLP6943 Core Practicum in Clinical Psychology
2015
CLP6905 Individual Work
2014
HSC4905 Individual Study
2012
GMS7795 Special Topics in Neuroscience
2008
HSC4970 Senior Honors Thesis

Contact Details

Phones:
Business:
(352) 273-6139
Emails:
Business:
wmp@phhp.ufl.edu